LD50 Values of Liposome-Based Constructs and Radiolabeled J591 Antibody
| LD50 (Bq/mL [μCi/mL]). | |||
| Incubation time (h) | LNCaP | Mat-Lu | HUVEC |
| 6 | |||
| J591-labeled liposomes | 3.70 × 102 (1.0 × 10−2) | 1.22 × 105 (3.3) | * |
| A10 aptamer–labeled liposomes | 3.22 × 104 (8.7 × 10−1) | 3.14 × 105 (8.5) | * |
| J591 antibody | 5.92 × 101 (1.6 × 10−3) | 3.29 × 104 (8.9 × 10−1) | 3.28 × 104 (8.9 × 10−1) |
| Nontargeted liposomes | 1.25 × 105 (3.4) | * | * |
| 24 | |||
| J591-labeled liposomes | 1.96 (5.3 × 10−5) | 2.92 × 102 (7.9 × 10−3) | 2.33 × 101 (6.3 × 10−4) |
| A10 aptamer- labeled liposomes | 37 (1.0 × 10−3) | 1.85 × 103 (5.0 × 10−2) | 4.07 × 103 (1.1 × 10−1) |
| J591 antibody | 1.37 (3.7 × 10−5) | 1.52 × 102 (4.1 × 10−3) | 1.11 × 102 (3.0 × 10−3) |
| Nontargeted liposomes | 1.52 × 104 (4.1 × 10−1) | 4.07 × 104 (1.1) | 5.55 × 103 (1.5 × 10−1) |
↵* LD50 not reached at highest concentration.