TABLE 3

Estimated Radiation Doses for 64Cu-DOTA-Trastuzumab*,

OrganEquivalent or effective dose per unit injected activity (mSv/MBq)Equivalent or effective dose per PET examination (mSv)
Heart wall0.1671
Kidneys0.0942
Liver0.1253
Red marrow0.0417
Spleen0.1045
Whole body0.0210
Effective dose0.0312
  • * Trastuzumab protein dose = 50 mg.

  • Calculations used averaged time–activity curves (8 patients) from our 111In-MxDTPA-trastuzumab study (9), which were normalized to averaged blood and organ uptake data from current 64Cu-DOTA-trastuzumab study (6 patients).

  • Assumes 64Cu injected activity = 450 MBq, average in current study.