Biodistribution of 111In-PC100 in Normal Mice
Time after injection (min) | ||||||
Organ | 1 | 5 | 20 | 60 | 120 | 240 |
Blood | 32.9 ± 4.08 | 30.1 ± 0.46 | 17.0 ± 5.99 | 5.75 ± 4.63 | 0.52 ± 0.49 | 1.58 ± 1.96 |
Intestine | 0.40 ± 0.05 | 0.46 ± 0.06 | 0.37 ± 0.16 | 0.28 ± 0.13 | 0.23 ± 0.10 | 0.59 ± 0.33 |
Kidney | 3.43 ± 0.50 | 3.51 ± 0.17 | 3.02 ± 0.96 | 2.28 ± 0.99 | 1.56 ± 0.38 | 3.39 ± 1.63 |
Liver | 6.34 ± 1.67 | 12.5 ± 2.66 | 28.1 ± 6.65 | 47.2 ± 5.75 | 53.8 ± 6.85 | 46.5 ± 13.4 |
Stomach | 0.45 ± 0.14 | 0.56 ± 0.23 | 0.43 ± 0.14 | 0.40 ± 0.16 | 0.39 ± 0.21 | 0.44 ± 0.14 |
Spleen | 5.16 ± 2.77 | 17.9 ± 3.20 | 101 ± 32.6 | 171 ± 69.4 | 174 ± 68.3 | 193 ± 53.7 |
Pancreas | 0.65 ± 0.14 | 0.66 ± 0.09 | 0.54 ± 0.25 | 0.32 ± 0.21 | 0.21 ± 0.19 | 0.84 ± 0.48 |
Lung | 18.9 ± 7.76 | 11.8 ± 1.51 | 6.62 ± 1.91 | 3.48 ± 2.55 | 0.64 ± 0.50 | 2.66 ± 2.20 |
Heart | 4.33 ± 0.88 | 3.31 ± 1.00 | 2.08 ± 0.76 | 0.78 ± 0.63 | 0.19 ± 0.07 | 0.53 ± 0.54 |
Each value represents mean ± SD (percentage injected dose per gram of tissue, n = 4 or 5).