TABLE 1

Biodistribution of ¹⁸F-LMI1195 and ¹²³I-MIBG in MENX Wild-Type Rats and MENX mut/mut Rats With and Without Previous Blocking of NET With Desipramine

	¹⁸F-LMI1195
Parameter	MENX wild-type	MENX mut/mut	MENX mut/mut	¹²³I-MIBG, MENX mut/mut
Time after injection	60 min	60 min	60 min	60 min
Blocking	None	None	Desipramine, 10 mg/kg	None
No. of rats	4	10	6	6
Animal weight	358 ± 101 g	445 ± 95 g	450 ± 115 g	443 ± 99 g
Organ (%ID/g × kg)
Blood	0.044 ± 0.005	0.030 ± 0.008 (P = 0.024^*)	0.024 ± 0.003 (P = 0.18)	0.035 ± 0.008 (P = 0.23)
Heart	0.90 ± 0.20	0.84 ± 0.19 (P = 0.57)	0.73 ± 0.26 (P = 0.42)	0.83 ± 0.11 (P = 0.59)
Liver	0.053 ± 0.012	0.051 ± 0.007 (P = 0.78)	0.34 ± 0.068 (P < 0.001^*)	0.300 ± 0.025 (P = 0.001^*)
Kidney	0.27 ± 0.079	0.35 ± 0.076 (P = 0.025^*)	0.60 ± 0.22 (P = 0.002^*)	0.29 ± 0.12 (P = 0.038^*)
Spleen	0.24 ± 0.060	0.25 ± 0.015 (P = 0.83)	0.10 ± 0.020 (P = 0.002^*)	0.28 ± 0.019 (P = 0.009^*)
Muscle	0.026 ± 0.003	0.025 ± 0.005 (P = 0.48)	0.027 ± 0.004 (P = 0.26)	0.020 ± 0.002 (P = 0.009^*)
Large intestine	0.18 ± 0.030	0.17 ± 0.012 (P = 0.39)	0.20 ± 0.046 (P = 0.39)	0.17 ± 0.014 (P = 0.52)
Small intestine	0.24 ± 0.067	0.31 ± 0.030 (P = 0.088)	0.34 ± 0.046 (P = 0.18)	0.43 ± 0.084 (P = 0.006^*)
Brain	0.012 ± 0.003	0.012 ± 0.005 (P = 0.67)	0.012 ± 0.003 (P = 1.0)	0.006 ± 0.003 (P = 0.037^*)
Lung	0.45 ± 0.11	0.35 ± 0.062 (P = 0.20)	0.29 ± 0.039 (P = 0.18)	0.56 ± 0.10 (P = 0.006^*)
Bone	0.17 ± 0.024	0.21 ± 0.054 (P = 0.20)	0.077 ± 0.010 (P = 0.002^*)	0.034 ± 0.006 (P = 0.004^*)
Adrenal gland (%ID)	0.092 ± 0.023	0.16 ± 0.047 (P < 0.001^*)	0.064 ± 0.013 (P < 0.001^*)	0.15 ± 0.028 (P = 0.60)

↵* Significant P values.
Biodistribution values are %ID ± SD for adrenal glands and %ID/g × kg ± SD for other organs. P values for nonblocked ¹⁸F-LMI1195 in MENX mut/mut rats are with respect to ¹⁸F-LMI1195 in wild-type rats. P values for other 2 categories are with respect to nonblocked ¹⁸F-LMI1195 in mut/mut rats.