TABLE 1

Biodistribution of 44Sc-cm09 in KB Tumor–Bearing Female Nude Mice

44Sc-cm09 (% injected dose per gram tissue*)
Organ2 h after injection4 h after injection8 h after injection20 h after injection
Blood3.74 ± 0.882.67 ± 0.351.77 ± 0.100.87 ± 0.08
Lung2.29 ± 0.421.84 ± 0.211.40 ± 0.100.90 ± 0.12
Spleen1.05 ± 0.190.90 ± 0.120.77 ± 0.010.70 ± 0.14
Kidneys19.21 ± 1.7022.61 ± 4.5221.30 ± 4.6222.22 ± 1.94
Stomach1.19 ± 0.171.01 ± 0.060.81 ± 0.030.58 ± 0.02
Intestines0.59 ± 0.160.53 ± 0.090.38 ± 0.050.36 ± 0.12
Liver3.63 ± 0.193.12 ± 0.383.56 ± 0.552.31 ± 0.15
Salivary glands6.49 ± 0.526.48 ± 0.294.51 ± 0.533.48 ± 0.57
Muscle1.07 ± 0.031.30 ± 0.611.12 ± 0.370.76 ± 0.28
Bone0.98 ± 0.041.04 ± 0.160.92 ± 0.0.90.68 ± 0.05
Tumor8.37 ± 0.4112.51 ± 1.7412.43 ± 1.0414.05 ± 2.29
Tumor to blood2.50 ± 0.593.79 ± 1.887.03 ± 0.6416.07 ± 1.71
Tumor to liver2.31 ± 0.113.25 ± 1.623.34 ± 0.436.07 ± 0.72
Tumor to kidney0.44 ± 0.030.45 ± 0.230.59 ± 0.060.63 ± 0.07
  • * Values shown represent mean ± SD of data from 3 animals (n = 3) per cohort.