Percentage displacement of 3H-CUMI-101 | ||||||||||||
(+)-8-OH-DPAT (50 nM) | Prazosin (50 nM) | |||||||||||
Rat | Monkey | Human | Rat | Monkey | Human | |||||||
Brain region | 37°C | 23°C | 37°C | 23°C | 37°C | 23°C | 37°C | 23°C | 37°C | 23°C | 37°C | 23°C |
Cortex | 47 ± 6 | 43 ± 4 | 91 ± 3 | 70 ± 4 | 87 ± 3 | 78 ± 2 | 42 ± 3 | 45 ± 2 | 12 ± 2 | 21 ± 1 | 10 ± 1 | 19 ± 2 |
Thalamus | 49 ± 2 | 39 ± 3 | 52 ± 3 | 28 ± 2 | 66 ± 2 | 46 ± 3 | 45 ± 2 | 51 ± 5 | 50 ± 4 | 78 ± 2 | 43 ± 1 | 56 ± 3 |
Cerebellum | 16 ± 2 | 11 ± 3 | 33 ± 3 | NA | NA | 25 ± 4 | 88 ± 4 | 91 ± 5 | 25 ± 3 | 79 ± 6 | NA | 89 ± 5 |
NA = 3 null entries for which we had no data.
Data are percentage displacement ± SEM.