TABLE 3

Results of Diagnostic Performance of 18F-FET PET Parameters to Identify Malignant Progression

Identification of malignant progressionIncrease of TBRmaxIncrease of TBRmeanDecrease of TTPChange of kinetic patternCombined analysisChange of contrast enhancement on MR imaging
Best threshold33%13%6 min*†Not applicable
Sensitivity72%72%72%72%83%44%
Specificity89%78%89%89%78%100%
Accuracy78%74%78%78%81%63%
AUC ± SE0.87 ± 0.070.80 ± 0.090.78 ± 0.10Not applicableNot applicableNot applicable
P value0.002‡0.014‡0.021‡0.004§0.004§0.026§
PPV93%87%93%93%88%100%
NPV62%58%62%62%70%47%

  • ↵* Change of kinetic pattern from pattern 1 to pattern 2 or 3.

  • ↵† Increase of TBRmax > 33% or change of TTP < −6 min or any increase of kinetic pattern.

  • ↵‡ ROC analysis.

  • ↵§ Fisher exact test.