TABLE 4

Contribution of PET/CT and CT/RECIST Response to PFS and OS Prediction

Model	Covariate	PFS			OS
Model	Covariate	R²	P^*	HR (95% confidence interval)	R²	P^*	HR (95% confidence interval)
Bottom	CT/RECIST	0.059		0.55 (0.25–1.22)	0.083		0.40 (0.14–1.14)
1		0.182	0.032		0.344	0.0009
	CT/RECIST			0.71 (0.32–1.61)			0.58 (0.20–1.68)
	Highest SUVmax			0.40 (0.17–0.95)			0.08 (0.01–0.62)
2		0.177	0.035		0.150	0.11
	CT/RECIST			0.76 (0.32–1.77)			0.49 (0.16–1.44)
	Highest TLG			0.38 (0.16–0.91)			0.42 (0.15–1.22)
3		0.182	0.032		0.344	0.0009
	CT/RECIST			0.71 (0.32–1.61)			0.58 (0.20–1.68)
	Total SUVmax			0.40 (0.17–0.95)			0.08 (0.01–0.62)
4		0.147	0.072		0.185	0.048
	CT/RECIST			0.74 (0.31–1.74)			0.56 (0.18–1.71)
	Total TLG			0.43 (0.18–1.04)			0.32 (0.11–0.99)
5		0.101	0.22		0.231	0.016
	CT/RECIST			0.57 (0.26–1.25)			0.41 (0.14–1.18)
	SUVmax by lesion			0.59 (0.25–1.41)			0.14 (0.02–1.12)
6		0.196	0.023		0.164	0.080
	CT/RECIST			0.73 (0.32–1.67)			0.52 (0.18–1.56)
	TLG by lesion			0.39 (0.17–0.87)			0.38 (0.12–1.16)

↵* From likelihood ratio test; each P value derives from comparison with bottom model.