TABLE 1

Pharmacokinetic Parameters of 3H-CHE and 14C-CHO Derived from 2-Compartment Analysis After Intravenous Injection of Triply Labeled Lipidots in Mice

Parameter14C3H
Half-life distribution (h)0.50 ± 0.130.41 ± 0.05
Half-life elimination (h)5.83 ± 0.47.9 ± 0.3
Mean residence time (h)7.0 ± 0.510.2 ± 0.8
Volume of distribution (mL)4.3 ± 0.85.2 ± 1
Systemic clearance (mL/h)0.62 ± 0.10.52 ± 0.14
  • Data are mean ± SD.