TABLE 1

Regional ¹¹C-Flumazenil BP_ND Values from Anesthetized and Awake Studies

ROI	Anesthetized (n = 4)	Awake (n = 6)	ΔBP_ND	P
Amygdala	1.08 ± 0.11	1.87 ± 0.77	−42%	0.08
Cerebellum	1.78 ± 0.33	1.56 ± 0.23	14%	0.26
Cingulate cortex	3.19 ± 0.46	3.73 ± 0.84	−14%	0.28
Frontal cortex	3.29 ± 0.49	3.34 ± 0.72	−2%	0.90
Insula	3.08 ± 0.39	3.29 ± 0.61	−6%	0.56
Occipital cortex	3.88 ± 0.30	4.01 ± 0.77	−3%	0.76
Temporal cortex	2.81 ± 0.33	2.77 ± 0.60	2%	0.89
Thalamus	1.39 ± 0.11	1.52 ± 0.39	−8%	0.55

Values are mean ± SD. Significance level was P < 0.05 (2-tailed, unpaired t test) of difference between anesthetized and awake scans.