Biodistribution Data of 99mTc-SARNC5 and 99mTc-SARNC6 in PC-3 Xenograft–Bearing SCID Mice
| 99mTc-SARNC5 | 99mTc-SARNC6 | |||||
| Organ | 1 h | 4 h | 24 h | 1 h | 4 h | 24 h |
| Blood | 1.08 ± 0.28 | 0.13 ± 0.02 (0.23 ± 0.05) | 0.04 ± 0.05 | 1.05 ± 0.29 | 0.06 ± 0.03 (0.35 ± 0.37) | 0.03 ± 0.01 |
| Liver | 1.39 ± 0.07 | 0.88 ± 0.35 (1.60 ± 0.37) | 0.43 ± 0.06 | 1.00 ± 0.15 | 0.70 ± 0.14 (1.74 ± 0.80) | 0.62 ± 0.23 |
| Heart | 0.60 ± 0.09 | 0.13 ± 0.02 (0.21 ± 0.02) | 0.13 ± 0.01 | 0.51 ± 0.15 | 0.07 ± 0.01 (0.25 ± 0.20) | 0.07 ± 0.07 |
| Kidneys | 20.49 ± 2.70 | 11.43 ± 2.09 (3.34 ± 0.41) | 4.90 ± 0.13 | 8.09 ± 1.31 | 3.15 ± 1.20 (5.52 ± 3.33) | 1.58 ± 0.41 |
| Stomach | 2.70 ± 032 | 1.49 ± 0.24 (0.38 ± 0.13) | 1.14 ± 0.57 | 0.75 ± 0.26 | 0.89 ± 0.25 (0.77 ± 0.57) | 0.45 ± 0.12 |
| Intestines | 11.64 ± 2.08 | 10.58 ± 1.05 2.34 ± 0.46 | 3.52 ± 0.24 | 3.85 ± 0.48 | 4.47 ± 0.82 2.65 ± 1.45 | 1.43 ± 0.54 |
| Spleen | 3.38 ± 0.98 | 2.66 ± 1.91 (3.35 ± 0.25) | 1.45 ± 0.09 | 2.03 ± 0.62 | 1.07 ± 0.35 (1.32 ± 0.85) | 1.19 ± 0.38 |
| Muscle | 0.26 ± 0.04 | 0.04 ± 0.01 (0.06 ± 0.03) | 0.03 ± 0.02 | 0.27 ± 0.09 | 0.03 ± 0.01 (0.09 ± 0.06) | 0.02 ± 0.01 |
| Lung | 1.58 ± 0.20 | 0.43 ± 0.05 (1.07 ± 0.29) | 0.36 ± 0.14 | 1.16 ± 0.22 | 0.44 ± 0.12 (1.23 ± 0.16) | 0.32 ± 0.04 |
| Pancreas | 131.58 ± 17.87 | 93.9 ± 24.06 (3.22 ± 0.28)* | 37.91 ± 3.01 | 25.93 ± 4.00 | 14.50 ± 1.34 (0.50 ± 0.14)* | 7.58 ± 1.89 |
| Tumor | 18.25 ± 5.11 | 9.57 ± 0.33 (0.72 ± 0.22)* | 6.26 ± 1.17 | 13.81 ± 3.12 | 9.22 ± 1.40 (0.60 ± 0.23)* | 6.96 ± 2.15 |
↵* Highly significant (P < 0.005) difference between blocked and unblocked animals (unpaired 2-tailed Student t test).
Values in parentheses at 4 h after injection represent animals coinjected with 40 nmol of Tyr4-BBN for in vivo GRPR blockade. Data presented are %ID/g tissue ± SD, n = 4.