TABLE 3

BPND and ΔBPND for Vehicle and MK-801 Challenges in 11C-ABP688 Small-Animal PET

Mean ± SD
RegionVehicle BPNDMK-801 BPNDVehicle–MK-801 ΔBPND
Caudate putamen2.49 ± 0.132.51 ± 0.280.6% ± 8.8%
Frontal cortex1.41 ± 0.131.46 ± 0.233.1% ± 15.3%
Cerebral cortex1.62 ± 0.101.64 ± 0.181.0% ± 9.9%
Hippocampus1.88 ± 0.111.83 ± 0.17−2.9% ± 9.4%
Thalamus1.03 ± 0.061.03 ± 0.120.7% ± 10.6%