TABLE 2

Multivariate Analysis of PFS, DSS, and OS Rates

	PFS		DSS		OS
Variable	HR	P	HR	P	HR	P
HPV-positive	0.35 (0.11–1.11)	0.075	0.31 (0.09–1.05)	0.059	0.31 (0.11–0.89)	0.029
≥52 y (median age)	0.37 (0.18–0.75)	0.006	0.43 (0.21–0.88)	0.020	0.58 (0.31–1.08)	0.088
Female vs. male	0.98 (0.09–10.68)	0.985	0.88 (0.08–10.02)	0.917	2.37 (0.46–12.29)	0.304
Tobacco use	1.79 (0.48–6.61)	0.385	1.29 (0.32–5.12)	0.722	1.80 (0.55–5.89)	0.329
T stage
T4 vs. T3	0.89 (0.38–2.08)	0.782	1.45 (0.57–3.73)	0.436	1.16 (0.52–2.62)	0.713
N stage
N0-N2a vs. N2b-N3	0.94 (0.38–2.36)	0.901	0.81 (0.32–2.03)	0.646	0.87 (0.38–1.99)	0.747
AJCC stage
Stage III vs. IVa vs. IVb	1.03 (0.48–2.19)	0.948	1.34 (0.61–2.96)	0.467	0.86 (0.43–1.76)	0.687
PET/CT parameters
SUV_max^*	0.99 (0.24–4.01)	0.983	0.60 (0.14–2.64)	0.498	0.56 (0.16–1.97)	0.363
Tumor TLG^†	7.15 (1.36–37.7)	0.020	7.28 (1.27–41.81)	0.026	5.85 (1.49–22.92)	0.011
Uniformity^‡	0.32 (0.16–0.64)	0.001	0.28 (0.13–0.57)	0.001	0.46 (0.24–0.87)	0.017

↵* SUV_max greater than cutoff of 12.87 vs. less than or equal to cutoff.
↵† TLG greater than cutoff of 121.9 g vs. less than or equal to cutoff.
↵‡ Tumor uniformity (4 bins) greater than cutoff of 0.138 vs. less than or equal to cutoff.
Data in parentheses are 95% CI.