TABLE 1

¹²³I-MNI-420 Kinetic Analysis Using 2T Model with Arterial Input Function, SRTM, Logan Reference, and SUVr Methods

Brain region	K₁ (mL/mL/min)	V_T (mL/mL)	BP_ND 2T arterial	BP_ND SRTM	BP_ND Logan reference	BP_ND SUVr method
Caudate	0.09 ± 0.01	3.18 ± 0.30	0.76 ± 0.14	0.68 ± 0.17	0.68 ± 0.15	0.76 ± 0.14
Putamen	0.14 ± 0.07	3.90 ± 0.91	1.16 ± 0.44	1.03 ± 0.33	1.04 ± 0.33	1.12 ± 0.31
Striatum	0.11 ± 0.04	3.58 ± 0.65	0.98 ± 0.31	0.86 ± 0.25	0.87 ± 0.24	0.94 ± 0.23
Frontal cortex	0.09 ± 0.03	2.07 ± 0.18	0.15 ± 0.03	0.08 ± 0.04	0.08 ± 0.04	0.09 ± 0.02
Parietal cortex	0.10 ± 0.03	2.07 ± 0.24	0.15 ± 0.06	0.11 ± 0.05	0.08 ± 0.02	0.09 ± 0.05
Temporal cortex	0.11 ± 0.04	2.16 ± 0.19	0.20 ± 0.08	0.14 ± 0.06	0.14 ± 0.06	0.16 ± 0.06
Occipital cortex	0.11 ± 0.03	2.01 ± 0.15	0.12 ± 0.06	0.09 ± 0.04	0.08 ± 0.02	0.09 ± 0.05
Cerebellum	0.11 ± 0.02	1.80 ± 0.13	—	—	—	—

Highest V_T and BP_ND values were determined in A_2A-rich regions (i.e., caudate, putamen, and striatum) for all investigated methods. Results presented as mean ± SD (n = 3). BP_ND SUVr method determined as average between 90 and 150 min after injection.