TABLE 1

Human AM (hAM) and Peptide Analogs Synthesized

CompoundSequencePurity (%)Theoretic molecular massObserved molecular mass
hAMTyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr986,028.826,028.18
hAM(13–52)Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr974,533.154,535.46
hAM(22–52)Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr953,576.033,578.58
1Gly-Gly-d-Ala-Gly-d-(PEG)4-hAM(22–52)924,064.164,065.55
2 (PulmoBind)Gly-Gly-d-Ala-Gly-Cys-d-(PEG)4-Cys-hAM(22–52)974,270.824,271.71
3Gly-Gly-d-Ala-Gly-Cys(Acm)-d-(PEG)4-Cys(Acm)-hAM(22–52)964,412.824,410.34
  • hAM = human AM; PEG = polyethylene glycol; Acm = acetamidomethyl.