Human AM (hAM) and Peptide Analogs Synthesized
Compound | Sequence | Purity (%) | Theoretic molecular mass | Observed molecular mass |
hAM | Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr | 98 | 6,028.82 | 6,028.18 |
hAM(13–52) | Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr | 97 | 4,533.15 | 4,535.46 |
hAM(22–52) | Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr | 95 | 3,576.03 | 3,578.58 |
1 | Gly-Gly-d-Ala-Gly-d-(PEG)4-hAM(22–52) | 92 | 4,064.16 | 4,065.55 |
2 (PulmoBind) | Gly-Gly-d-Ala-Gly-Cys-d-(PEG)4-Cys-hAM(22–52) | 97 | 4,270.82 | 4,271.71 |
3 | Gly-Gly-d-Ala-Gly-Cys(Acm)-d-(PEG)4-Cys(Acm)-hAM(22–52) | 96 | 4,412.82 | 4,410.34 |
hAM = human AM; PEG = polyethylene glycol; Acm = acetamidomethyl.