TABLE 1

Analytic Data for SARNCs

SARNCPeptide conjugatePercentage puritytR* (min)Molecular weight† calculated, m/zMolecular weight† found, m/z
SARNC1[N40]GRP(18-27)≥958.31,307.5 [M-H]+1,306.9 [M-H]+
SARNC2[N40,dAla24]GRP(18-27)≥988.31,321.6 [M-H]+1,321.9 [M-H]+
SARNC3[N40,dAla24,Nle27]GRP(18-27)≥999.91,305.5 [M-H]+1,305.6 [M-H]+
SARNC4[N40,dAla24,Leu27]GRP(18-27)≥989.81,305.5 [M-H]+1,305.6 [M-H]+
SARNC5[N40,βAla24]GRP(18-27)≥989.11,321.6 [M-H]+1,321.4 [M-H]+
SARNC6[N40,Sar24]GRP(18-27)≥998.71,321.6 [M-H]+1,321.4 [M-H]+

  • ↵* Nucleosil-100 C18 column (150 × 4 mm) was eluted at flow rate of 1 mL/min with linear gradient: 0.1% TFA in MeCN (10%–90% in 30 min) and 0.1% aqueous TFA as complementary phase; runs were monitored by ultraviolet detection at 215 nm.

  • ↵† Average mass.