Binding Values and Percentage Change of 11C-PIB According to Analytic Method
| Method | AD | MCI | Control | All |
| RPM2 (BPND + 1) | ||||
| Baseline | 1.87 ± 0.10 | 1.39 ± 0.39 | 1.12 ± 0.27 | 1.40 ± 0.41 |
| Follow-up | 1.86 ± 0.13 | 1.46 ± 0.39 | 1.15 ± 0.29 | 1.44 ± 0.41 |
| Percentage change | −0.3 ± 5.9 | 5.5 ± 7.4* | 1.9 ± 3.2† | 2.7 ± 6.0* |
| Logan DVR | ||||
| Baseline | 1.70 ± 0.08 | 1.31 ± 0.32 | 1.08 ± 0.23 | 1.32 ± 0.34 |
| Follow-up | 1.68 ± 0.10 | 1.37 ± 0.32 | 1.11 ± 0.24 | 1.35 ± 0.33 |
| Percentage change | −1.0 ± 5.2 | 5.3 ± 6.0‡ | 2.1 ± 3.5* | 2.6 ± 5.4‡ |
| SUVr60–90 | ||||
| Baseline | 2.16 ± 0.09 | 1.57 ± 0.52 | 1.26 ± 0.38 | 1.59 ± 0.52 |
| Follow-up | 2.07 ± 0.22 | 1.67 ± 0.50 | 1.29 ± 0.35 | 1.62 ± 0.49 |
| Percentage change | −4.3 ± 8.6 | 8.0 ± 9.2‡ | 2.6 ± 4.2 | 2.9 ± 8.7 |
| SUVr40–60 | ||||
| Baseline | 2.02 ± 0.10 | 1.54 ± 0.46 | 1.21 ± 0.32 | 1.53 ± 0.46 |
| Follow-up | 2.02 ± 0.19 | 1.62 ± 0.46 | 1.28 ± 0.35 | 1.59 ± 0.46 |
| Percentage change | 0.1 ± 6.4 | 5.5 ± 7.4* | 5.8 ± 6.1‡ | 4.3 ± 6.9‡ |
Level of significance for percentage change and for differences between baseline and follow-up values: *P = 0.06; †P = 0.07; ‡P < 0.05.