99mTc-SARNC3 | 99mTc-SARNC4 | |||||
Organ | 1 h | 4 h | 24 h | 1 h | 4 h | 24 h |
Blood | 1.30 ± 0.24 | 0.11 ± 0.05 (0.19 ± 0.01) | 0.07 ± 0.01 | 0.98 ± 0.32 | 0.09 ± 0.02 (0.72 ± 0.60) | 0.06 ± 0.02 |
Liver | 1.04 ± 0.16 | 0.58 ± 0.15 (1.07 ± 0.09) | 0.15 ± 0.03 | 0.93 ± 0.27 | 0.50 ± 0.10 (1.42 ± 0.54) | 0.14 ± 0.03 |
Heart | 0.65 ± 0.15 | 0.10 ± 0.01 (0.27 ± 0.05) | 0.07 ± 0.01 | 0.59 ± 0.19 | 0.07 ± 0.01 (0.48 ± 0.41) | 0.10 ± 0.03 |
Kidneys | 9.98 ± 0.82 | 3.91 ± 0.77 (5.97 ± 0.92) | 1.36 ± 0.24 | 7.65 ± 1.22 | 3.35 ± 0.36 (9.21 ± 4.99) | 1.57 ± 0.90 |
Stomach | 2.04 ± 0.60 | 1.92 ± 0.80 (2.73 ± 0.80) | 0.92 ± 0.19 | 1.51 ± 0.59 | 1.18 ± 0.30 (2.86 ± 0.99) | 0.50 ± 0.12 |
Intestines | 4.27 ± 0.64 | 4.16 ± 0.86 (3.27 ± 0.52) | 1.29 ± 0.08 | 3.08 ± 0.58 | 2.76 ± 0.51 (3.21 ± 2.34) | 0.95 ± 0.28 |
Spleen | 1.27 ± 0.20 | 0.85 ± 0.10 (1.27 ± 0.17) | 0.44 ± 0.11 | 1.07 ± 0.27 | 0.61 ± 0.20 (1.61 ± 0.56) | 0.45 ± 0.18 |
Muscle | 0.28 ± 0.07 | 0.04 ± 0.02 (0.12 ± 0.46) | 0.04 ± 0.01 | 0.22 ± 0.08 | 0.06 ± 0.05 (0.25 ± 0.19) | 0.05 ± 0.02 |
Lung | 1.16 ± 0.23 | 0.22 ± 0.06 (0.54 ± 0.07) | 0.08 ± 0.01 | 0.92 ± 0.28 | 0.17 ± 0.05 (0.80 ± 0.45) | 0.10 ± 0.03 |
Pancreas | 16.26 ± 2.93 | 11.0 ± 0.61 (0.39 ± 0.06)* | 3.20 ± 0.37 | 9.59 ± 2.84 | 5.65 ± 1.16 (0.49 ± 0.17)* | 2.22 ± 0.56 |
Tumor | 6.97 ± 1.36 | 4.79 ± 0.81 (0.62 ± 0.10)* | 1.81 ± 0.20 | 7.51 ± 1.90 | 4.39 ± 0.64 (1.13 ± 0.64)* | 2.73 ± 0.78 |
↵* Highly significant (P < 0.005) difference between blocked and unblocked animals (unpaired 2-tailed Student t test).
Values in parentheses at 4 h after injection represent animals coinjected with 40 nmol of Tyr4-BBN for in vivo GRPR blockade. Data presented are %ID/g tissue ± SD, n = 4.