Biodistribution Studies in PC-3 Tumor–Bearing SCID Mice
| Tissue (%ID/g) | 1 h after injection | 4 h after injection | 24 h after injection | 48 h after injection | 72 h after injection |
| 111In-1 | |||||
| Blood | 0.11 ± 0.22 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Heart | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Lung | 0.21 ± 0.40 | 0.02 ± 0.03 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Liver | 0.40 ± 0.32 | 0.09 ± 0.11 | 0.03 ± 0.03 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Pancreas | 70.96 ± 15.88 | 37.17 ± 10.52 | 12.07 ± 3.05 | 6.51 ± 2.26 | 0.00 ± 0.00 |
| Stomach | 5.87 ± 3.63 | 1.02 ± 0.72 | 0.34 ± 0.26 | 0.11 ± 0.23 | 0.00 ± 0.00 |
| Small intestine (%ID) | 8.15 ± 2.93 | 2.04 ± 0.59 | 0.96 ± 0.52 | 0.66 ± 0.18 | 0.02 ± 0.04 |
| Large intestine (%ID) | 5.07 ± 1.26 | 4.74 ± 2.08 | 1.62 ± 0.54 | 1.71 ± 0.87 | 0.46 ± 0.28 |
| Kidney | 13.41 ± 5.84 | 4.82 ± 1.60 | 2.18 ± 0.67 | 1.38 ± 1.01 | 0.76 ± 0.67 |
| Tumor | 5.82 ± 2.63 | 2.16 ± 1.01 | 1.32 ± 0.62 | 0.83 ± 0.48 | 0.09 ± 0.10 |
| Muscle | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Bone | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Brain | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Excretion* (%ID) | 35.88 ± 14.38 | 82.06 ± 4.65 | 91.07 ± 1.75 | 93.42 ± 3.26 | 98.44 ± 0.48 |
| 111In-2 | |||||
| Blood | 1.21 ± 0.61 | 0.00 ± 0.00 | 0.02 ± 0.02 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Heart | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Lung | 1.21 ± 0.98 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Liver | 0.87 ± 0.38 | 0.15 ± 0.05 | 0.13 ± 0.05 | 0.08 ± 0.01 | 0.06 ± 0.02 |
| Pancreas | 33.70 ± 27.11 | 14.01 ± 13.97 | 1.98 ± 1.35 | 0.25 ± 0.17 | 0.22 ± 0.12 |
| Stomach | 1.51 ± 1.69 | 0.49 ± 0.20 | 0.06 ± 0.08 | 0.07 ± 0.09 | 0.04 ± 0.08 |
| Small intestine (%ID) | 4.62 ± 1.42 | 1.44 ± 0.61 | 0.23 ± 0.10 | 0.12 ± 0.06 | 0.02 ± 0.02 |
| Large intestine (%ID) | 2.02 ± 0.7 | 3.82 ± 1.11 | 0.57 ± 0.18 | 0.35 ± 0.14 | 0.15 ± 0.04 |
| Kidney | 14.88 ± 4.55 | 5.09 ± 1.70 | 3.74 ± 1.65 | 2.03 ± 0.42 | 2.66 ± 0.73 |
| Tumor | 6.06 ± 3.35 | 1.89 ± 0.92 | 1.08 ± 0.49 | 0.58 ± 0.24 | 0.41 ± 0.07 |
| Muscle | 1.69 ± 1.72 | 0.12 ± 0.25 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Bone | 0.71 ± 0.42 | 0.14 ± 0.15 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Brain | 0.02 ± 0.05 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Excretion* (%ID) | 17.26 ± 15.53 | 81.24 ± 8.28 | 94.89 ± 0.67 | 96.10 ± 0.61 | 95.90 ± 0.95 |
| 111In-4 | |||||
| Blood | 0.75 ± 0.54 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Heart | 0.73 ± 1.46 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Lung | 0.61 ± 1.04 | 0.41 ± 0.82 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Liver | 0.38 ± 0.36 | 0.30 ± 0.24 | 0.20 ± 0.45 | 0.45 ± 0.33 | 0.01 ± 0.02 |
| Pancreas | 33.04 ± 19.50 | 7.73 ± 2.70 | 0.62 ± 1.25 | 0.06 ± 0.12 | 0.00 ± 0.00 |
| Stomach | 0.50 ± 0.75 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Small intestine (%ID) | 3.18 ± 1.77 | 1.00 ± 0.59 | 0.25 ± 0.18 | 0.01 ± 0.01 | 0.09 ± 0.14 |
| Large intestine (%ID) | 2.16 ± 0.94 | 2.38 ± 1.05 | 0.83 ± 0.16 | 0.57 ± 0.33 | 0.24 ± 0.27 |
| Kidney | 17.90 ± 10.88 | 25.79 ± 4.66 | 23.40 ± 12.33 | 12.87 ± 2.76 | 8.83 ± 5.69 |
| Tumor | 2.80 ± 1.18 | 1.43 ± 0.62 | 0.92 ± 0.46 | 0.69 ± 0.53 | 0.60 ± 0.40 |
| Muscle | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Bone | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Brain | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Excretion* (%ID) | 61.95 ± 23.27 | 80.86 ± 2.63 | 87.21 ± 2.75 | 91.55 ± 1.73 | 93.85 ± 2.78 |
↵* Excretion values were calculated using activity values associated with excreted urine, bladder, and fecal material contents at time of sacrifice.
Organ uptake values expressed as %ID/g and values are mean ± SD (n = 4) unless otherwise noted.