Outcome Results of 2 Mixed-Effects Models
| Model | Fixed effect | Estimate | P |
| 1 | |||
| ADAS_cog | time:MCI | 1.6 | 0.0001 |
| rFTC | time:MCI | −0.02 | 0.0001 |
| MMSE | time:MCI | −0.82 | 0.0002 |
| FAQ | time:MCI | 2.5 | 0.0001 |
| 2 | |||
| ADAS_cog | time:APOE | 1.14 | 0.001 |
| rFTC | time:APOE | −0.014 | 0.008 |
| MMSE | time:APOE | −0.44 | 0.007 |
| FAQ | time:APOE | 1.32 | 0.0001 |
Both models were performed for rFTC(t), MMSE(t), ADAS-cog(t), and FAQ(t) as outcome variables. With the first model (time:MCI), we see how changes in these variables over time differed between MCI and normal subjects. Second model (time:APOE) shows how changes in these variables over time differed between the group with positive APOE-ε4 and control group.