TABLE 2

Results from Compartmental Modeling and Patlak Analysis of 11C-GMO Kinetics

Compartmental modeling
StudyK1 (mL/min/g)k2 (min−1)k3 (min−1)BVKi (mL/min/g)Patlak analysis, Kp (mL/min/g)
Control
 A0.3920.1450.0740.3220.1330.104
 B0.3450.1230.0820.2830.1380.111
 C0.3060.0820.0610.2780.1310.102
 D0.2820.1170.0870.2520.1200.099
Desipramine dose
 0.01 mg/kg
  A0.2450.1290.0990.3430.1060.077
  B0.2590.1380.0890.3560.1010.073
 0.0316 mg/kg
  A0.2710.2550.1140.3610.0840.062
  B0.2560.1880.0940.3260.0850.064
 0.1 mg/kg
  A0.4170.7940.1490.4110.0660.047
  B0.2170.2400.1130.3700.0690.051
 0.316 mg/kg0.6622.2280.1200.2150.0340.030
 1.0 mg/kg0.1020.4350.0740.5920.0150.017
  • Net uptake rate constants Ki were calculated from estimated parameter values as (K1k3)/(k2 + k3).