Compartmental modeling | ||||||
Study | K1 (mL/min/g) | k2 (min−1) | k3 (min−1) | BV | Ki (mL/min/g) | Patlak analysis, Kp (mL/min/g) |
Control | ||||||
A | 0.392 | 0.145 | 0.074 | 0.322 | 0.133 | 0.104 |
B | 0.345 | 0.123 | 0.082 | 0.283 | 0.138 | 0.111 |
C | 0.306 | 0.082 | 0.061 | 0.278 | 0.131 | 0.102 |
D | 0.282 | 0.117 | 0.087 | 0.252 | 0.120 | 0.099 |
Desipramine dose | ||||||
0.01 mg/kg | ||||||
A | 0.245 | 0.129 | 0.099 | 0.343 | 0.106 | 0.077 |
B | 0.259 | 0.138 | 0.089 | 0.356 | 0.101 | 0.073 |
0.0316 mg/kg | ||||||
A | 0.271 | 0.255 | 0.114 | 0.361 | 0.084 | 0.062 |
B | 0.256 | 0.188 | 0.094 | 0.326 | 0.085 | 0.064 |
0.1 mg/kg | ||||||
A | 0.417 | 0.794 | 0.149 | 0.411 | 0.066 | 0.047 |
B | 0.217 | 0.240 | 0.113 | 0.370 | 0.069 | 0.051 |
0.316 mg/kg | 0.662 | 2.228 | 0.120 | 0.215 | 0.034 | 0.030 |
1.0 mg/kg | 0.102 | 0.435 | 0.074 | 0.592 | 0.015 | 0.017 |
Net uptake rate constants Ki were calculated from estimated parameter values as (K1k3)/(k2 + k3).