TABLE 1

Characteristics of Lung Injury, Ventilatory Settings, and PET Measurements in Experimental Groups

CharacteristicLow-PEEP group in SP (n = 9)High-PEEP group in SP (n = 8)Low-PEEP group in PP (n = 9)VILI group with HCl (n = 6)VILI group without HCl (n = 6)Control group (n = 6)
HCl-induced ALIYesYesYesYesNoNo
Protective ventilationYesYesYesNoNoYes
VT (mL⋅kg−1)9 ± 1 (7–11)7 ± 1 (5–8)10 ± 1 (8–10)31 ± 10 (17–44)57 ± 10 (42–71)10 ± 0 (10–10)
PEEP (cm of H2O)5 ± 3 (2–10)12 ± 1 (11–15)6 ± 3 (2–10)0 ± 0 (0–0)0 ± 0 (0–0)3 ± 0 (3–3)
Pplat,rs (cm of H2O)27 ± 3 (22–32)27 ± 1 (26–29)25 ± 4 (20–33)53 ± 9 (43–66)48 ± 3 (45–52)16 ± 4 (12–22)
FB (mL of blood⋅100 mL of lung−1)*5 ± 3 (0–14)4 ± 3 (0–10)5 ± 2 (1–9)3 ± 2 (0–9)6 ± 5 (0–25)7 ± 4 (2–15)
PBF (mL⋅min−1⋅100 mL of lung−1)134 ± 98 (8–403)134 ± 113 (6–537)140 ± 64 (31–290)99 ± 64 (12–254)219 ± 170 (12–723)263 ± 169 (24–603)
  • * Assessed with PET and compartmental modeling of 18F-FDG kinetics.

  • Assessed with PET and 15O-H2O.

  • SP = supine position; PP = prone position; Pplat,rs = plateau pressure of respiratory system.

  • Data are reported as mean ± SD (range), unless otherwise indicated.