Imaging Protocol for 82Rb PET MPI
| Feature | Technique | |
| Stress testing | Pharmacologic agents | Standard |
| Tracer dose | Standard | |
| 2-dimensional scanner | 1,480–2,220 MBq (40–60 mCi) | Standard |
| 3-dimensional scanner | 370–740 MBq (10–20 mCi) | Standard |
| 2,220–1,480 MBq (30–40 mCi) for lutetium oxyorthosilicate systems | ||
| Injection rate | Bolus of ≤30 s | Standard |
| Imaging delay after injection | LVEF > 50%: 70–90 s | Acceptable |
| LVEF ≤ 50% or unknown: 90–130 s | ||
| List mode: acquire immediately | ||
| Patient positioning | Standard | |
| PET | Scout scan: 370–740 MBq (10–20 mCi) 82Rb | |
| Transmission scan | Optional | |
| PET/CT | CT scout | Standard |
| Imaging mode | List mode/gated/dynamic (no delay after injection) | Preferred |
| Gated (delay after injection) | Optional | |
| Imaging duration | 3–6 min | Standard |
| 3–10 min | Optional | |
| Attenuation correction | Measured attenuation correction, before or after | Standard |
| Reconstruction method | FBP or iterative expectation maximization (OSEM) | Standard |
| Reconstruction filter | Sufficient to achieve desired resolution/smoothing, matched stress to rest | Standard |
| Reconstructed pixel size | 2–3 mm | Preferred |
LVEF = left ventricular ejection fraction; FBP = filtered backprojection; OSEM = ordered-subsets expectation maximization.
Reproduced with permission from (6).