TABLE 2

Biodistribution of ¹¹C-SA4503 in Brain and Peripheral Regions

	SUV			Tissue-to-plasma ratio
Tissue	Normal aged (n = 7)	With tumor (n = 5)	P	Normal aged (n = 7)	With tumor (n = 5)	P
Cerebellum	1.21 ± 0.12	2.08 ± 0.25	<0.001	7.06 ± 1.01	20.67 ± 1.92	<0.001
Cerebral cortex	1.55 ± 0.05	2.31 ± 0.16	<0.01	8.97 ± 0.79	23.30 ± 2.13	<0.001
Rest of brain	1.28 ± 0.05	1.87 ± 0.18	<0.05	7.41 ± 0.70	18.54 ± 1.14	<0.001
Adipose tissue	0.32 ± 0.10	0.38 ± 0.19	NS	1.91 ± 0.65	3.59 ± 1.74	NS
Bladder	3.09 ± 1.29	2.28 ± 0.93	NS	19.81 ± 9.26	22.82 ± 8.62	NS
Bone	0.43 ± 0.08	0.62 ± 0.08	NS	2.48 ± 0.55	6.45 ± 1.20	NS
Bone marrow	3.55 ± 1.10	2.72 ± 0.90	NS	18.77 ± 5.09	27.10 ± 8.72	NS
Heart	0.61 ± 0.05	0.93 ± 0.05	NS	3.49 ± 0.37	9.43 ± 1.00	NS
Large intestine	2.41 ± 0.27	2.94 ± 0.15	NS	14.30 ± 2.35	30.74 ± 5.18	NS
Small intestine	3.50 ± 0.38	5.41 ± 0.52	NS	20.26 ± 3.07	55.59 ± 8.43	<0.01
Kidney	3.50 ± 0.25	4.08 ± 0.55	NS	20.40 ± 2.34	41.62 ± 6.77	NS
Liver	11.05 ± 0.63	11.68 ± 1.15	NS	63.83 ± 5.83	115.42 ± 6.67	<0.001
Lung	2.21 ± 0.14	3.85 ± 0.60	NS	12.71 ± 1.18	39.32 ± 6.93	NS
Muscle	0.30 ± 0.06	0.47 ± 0.08	NS	1.70 ± 0.32	4.83 ± 0.92	NS
Pancreas	5.74 ± 1.01	5.31 ± 0.77	NS	33.23 ± 6.82	55.07 ± 10.28	NS
Plasma	0.18 ± 0.01	0.10 ± 0.01	NS	1.00	1.00	NS
Red blood cells	0.09 ± 0.02	0.06 ± 0.01	NS	0.50 ± 0.10	0.64 ± 0.06	NS
Spleen	4.10 ± 0.29	5.77 ± 0.77	NS	24.13 ± 3.13	58.12 ± 7.82	<0.01
Submandibular gland	6.67 ± 0.83	4.90 ± 0.97	NS	37.24 ± 3.93	53.76 ± 16.45	NS
Urine	4.76 ± 2.07	3.676 ± 1.69	NS	31.26 ± 14.76	40.07 ± 18.42	NS

NS = not statistically significant.
Data are expressed as mean ± SEM.