Log P and Brain Uptake After Intravenous Administration of 18F-Labeled Compounds in Mice
| Brain uptake (%ID/g) | |||||
| Compound | Log P | 2 min after injection | 30 min after injection | 60 min after injection | Brain uptake ratio (2 min/60 min) |
| 18F-THK-523 | 2.40 | 2.72 | 1.47 | 1.46 | 1.86 |
| 18F-THK-5105 | 3.03 | 9.20 | 3.61 | 1.00 | 9.20 |
| 18F-THK-5116 | 1.57 | 3.36 | 0.75 | 0.57 | 5.89 |
| 18F-THK-5117 | 2.32 | 6.06 | 0.59 | 0.26 | 23.1 |
| 18F-FDDNP | 3.71 | 6.23 | 2.02 | 2.14 | 2.91 |