Bolus-and-Infusion Equilibrium Measurement: In Vivo Binding Parameters Obtained with Metabolite-Corrected Plasma Input Function in 5 Brain Regions
| VT (mL/cm3) | |||||
| Region | 1TCM | 2TCM | MA1 | GA | TPR |
| Olfactory bulb | 0.5 ± 0.23 (46%) | 0.54 ± 0.24 (44%) | 0.59 ± 0.24 (41%) | 0.57 ± 0.23 (41%) | 0.52 ± 0.22 (43%) |
| Caudate–putamen | 1.54 ± 0.78 (51%) | 1.57 ± 0.79 (50%) | 1.57 ± 0.77 (49%) | 1.55 ± 0.75 (49%) | 1.63 ± 0.87 (53%) |
| Cerebellum gray matter | 1.47 ± 0.74 (50%) | 1.5 ± 0.76 (51%) | 1.52 ± 0.74 (49%) | 1.51 ± 0.73 (48%) | 1.56 ± 0.84 (54%) |
| Cortex | 1.11 ± 0.57 (51%) | 1.14 ± 0.59 (52%) | 1.18 ± 0.58 (49%) | 1.17 ± 0.56 (48%) | 1.18 ± 0.64 (54%) |
| Hippocampus | 1.62 ± 0.8 (49%) | 1.64 ± 0.83 (50%) | 1.67 ± 0.81 (48%) | 1.65 ± 0.78 (47%) | 1.72 ± 0.9 (52%) |
GA = graphical analysis; TPR = tissue-to-plasma ratio.
n = 8 (±SD and coefficient of variation in %).