TABLE 1

Reaction Conditions and Yields for ¹⁸F-FDM Synthesis from Precusor-1

Precursor-1		K₂CO₃ (µmol)	¹⁸F (GBq)	¹⁸F-fluorination time (min)^*	Deprotection^*		Yield (%)^†
mg	µmol	K₂CO₃ (µmol)	¹⁸F (GBq)	¹⁸F-fluorination time (min)^*	Acid	Time (min)	Yield (%)^†
5.0	11	14.4	2.30	30	5 M HCl, 1.0 mL	30	70
5.0	11	9.9	2.00	30	5 M HCl, 1.5 mL	30	64
3.0	6.4	14.4	3.44	30	6 M HCl, 1.0 mL	30	68
3.0	6.4	6.6	3.47	30	6 M HCl, 1.0 mL	30	50
3.0	6.4	16.5	1.88	10	6 M HCl, 1.0 mL	20	60
3.0	6.4	6.6	2.44	10	6 M HCl, 1.0 mL	10	43

↵* Fluorination and deprotection were performed at 110°C.
↵† Decay-corrected radiochemical yield.
Acetonitrile (reaction solvent) was not removed by evaporation after fluorination.