TABLE 2

Biodistribution of ^99mTc-B2702p1-20 at 180 Minutes After Injection in ApoE^−/− Mice with Left Carotid Artery Ligation

Tracer	Heart	Aorta	Lung	Liver	Spleen	Kidney	Fat	Muscle	Blood	Thyroid	L. carotid	R. carotid
^99mTc-B2702p	1.5 ± 0.1	2.7 ± 0.4	3.9 ± 0.4	10.6 ± 2.6	2.2 ± 0.3	69.0 ± 13.0	1.0 ± 0.2	1.2 ± 0.2	5.7 ± 0.6	9.7 ± 3.0	2.4 ± 0.4	1.8 ± 0.3
^99mTc-B2702p1	0.3 ± 0.1	0.5 ± 0.1	0.8 ± 0.1	3.1 ± 0.6	1.6 ± 0.7	4.6 ± 0.5	0.2 ± 0.0	0.1 ± 0.0	0.9 ± 0.2^†	0.7 ± 0.2	1.3 ± 0.4*	0.5 ± 0.1^†
^99mTc-B2702p1 mismatch	0.7 ± 0.2	1.7 ± 0.7	1.7 ± 0.4	22.1 ± 5.9	0.8 ± 0.1	15.5 ± 4.2	0.5 ± 0.2	0.5 ± 0.1	2.4 ± 0.8	1.1 ± 0.4	1.2 ± 0.6	1.2 ± 0.6
^99mTc-B2702p2	0.3 ± 0.1	0.9 ± 0.6	0.8 ± 0.3	2.7 ± 0.3	1.4 ± 0.4	13.4 ± 1.9	0.3 ± 0.2	0.2 ± 0.1	0.9 ± 0.3^†	1.3 ± 0.1	0.5 ± 0.2^†	0.3 ± 0.1^†
^99mTc-B2702p3	0.4 ± 0.1	0.7 ± 0.2	0.9 ± 0.2	4.2 ± 0.6	0.8 ± 0.2	33.1 ± 0.7	0.3 ± 0.1	0.2 ± 0.1	1.3 ± 0.3^†	0.6 ± 0.1	0.5 ± 0.1^†	0.4 ± 0.1^†
^99mTc-B2702p4	0.3 ± 0.1	0.6 ± 0.3	0.6 ± 0.2	4.7 ± 0.9	0.6 ± 0.2	26.2 ± 5.1	0.2 ± 0.1	0.2 ± 0.1	0.9 ± 0.4^†	0.6 ± 0.2	0.7 ± 0.4^†	0.2 ± 0.1^†
^99mTc-B2702p6	0.3 ± 0.0	0.6 ± 0.0	0.7 ± 0.0	5.9 ± 1.0	0.5 ± 0.0	8.2 ± 0.7	0.2 ± 0.0	0.1 ± 0.0	1.1 ± 0.1^†	1.5 ± 0.3	0.5 ± 0.1^†	0.4 ± 0.2^†
^99mTc-B2702p7	0.4 ± 0.0	0.7 ± 0.1	0.9 ± 0.1	8.2 ± 0.4	1.0 ± 0.3	8.0 ± 1.3	0.2 ± 0.0	0.2 ± 0.0	1.3 ± 0.1^†	1.9 ± 0.7	0.4 ± 0.2^†	0.4 ± 0.2^†
^99mTc-B2702p8	0.3 ± 0.1	0.7 ± 0.1	0.9 ± 0.1	6.9 ± 1.6	0.8 ± 0.2	20.6 ± 10.8	0.2 ± 0.1	0.2 ± 0.1	1.2 ± 0.3^†	1.6 ± 0.6	0.4 ± 0.1^†	0.2 ± 0.1^†
^99mTc-B2702p9	0.1 ± 0.0	0.3 ± 0.0	0.4 ± 0.0	2.1 ± 0.1	0.4 ± 0.1	2.2 ± 0.2	0.1 ± 0.0	0.1 ± 0.0	0.4 ± 0.0^†	0.4 ± 0.0	0.1 ± 0.0^†	0.1 ± 0.0^†
^99mTc-B2702P10	0.5 ± 0.3	0.3 ± 0.0	0.4 ± 0.1	2.8 ± 0.5	0.4 ± 0.1	23.6 ± 3.7	0.1 ± 0.0	0.1 ± 0.0	0.4 ± 0.0^†	0.3 ± 0.0	0.1 ± 0.0^†	0.4 ± 0.2^†
^99mTc-B2702p11	1.8 ± 0.1	2.7 ± 0.1	3.6 ± 0.3	10.8 ± 0.6	2.9 ± 0.1	19.2 ± 0.8	1.5 ± 0.3	0.6 ± 0.1	6.7 ± 0.4	14.2 ± 6.9	2.1 ± 0.3	1.9 ± 0.7
^99mTc-B2702p12	0.4 ± 0.1	2.8 ± 0.9	4.2 ± 1.5	5.5 ± 0.6	3.1 ± 0.2	36.9 ± 11.4	0.8 ± 0.1	0.8 ± 0.4	4.4 ± 1.2	8.8 ± 2.8	2.1 ± 0.9	1.4 ± 0.4
^99mTc-B2702p13	1.6 ± 0.3	2.3 ± 0.3	3.3 ± 0.4	8.0 ± 0.6	2.9 ± 0.4	22.7 ± 7.5	0.8 ± 0.3	0.5 ± 0.1	5.9 ± 0.5	11.0 ± 3.2	1.7 ± 0.3	1.8 ± 0.4
^99mTc-B2702p14	2.5 ± 0.7	3.2 ± 0.6	5.7 ± 1.4	12.7 ± 2.4	3.7 ± 1.0	34.6 ± 1.9	0.8 ± 0.1	0.7 ± 0.2	10.7 ± 2.2	15.9 ± 2.6	2.2 ± 0.2	2.2 ± 0.2
^99mTc-B2702p15	4.5 ± 0.3	5.2 ± 0.1	11.2 ± 0.7	18.1 ± 0.7	6.4 ± 0.2	34.0 ± 4.4	1.6 ± 0.7	1.2 ± 0.1	16.4 ± 0.9	6.3 ± 1.1	3.3 ± 0.7	1.9 ± 0.5
^99mTc-B2702p16	0.3 ± 0.0	0.6 ± 0.1	0.9 ± 0.1	3.4 ± 0.4	1.2 ± 0.1	98.9 ± 18.1	0.4 ± 0.1	0.2 ± 0.0	1.0 ± 0.1^†	1.7 ± 0.2	0.4 ± 0.0^†	0.4 ± 0.2^†
^99mTc-B2702p17	0.4 ± 0.1	0.6 ± 0.2	1.2 ± 0.5	3.5 ± 1.2	1.6 ± 0.7	85.3 ± 25.7	0.3 ± 0.1	0.3 ± 0.2	1.3 ± 0.4^†	2.8 ± 0.4	0.4 ± 0.1^†	0.2 ± 0.1^†
^99mTc-B2702p18	0.5 ± 0.1	2.5 ± 0.4	3.2 ± 0.5	6.3 ± 1.5	2.3 ± 0.7	63.9 ± 17.2	1.2 ± 0.5	0.7 ± 0.0	5.9 ± 1.0	18.8 ± 2.7	2.0 ± 0.2*	1.0 ± 0.1^†
^99mTc-B2702p19	0.5 ± 0.1	0.9 ± 0.3	1.3 ± 0.2	5.5 ± 0.5	1.5 ± 0.1	15.2 ± 6.0	0.2 ± 0.0	0.3 ± 0.0	2.0 ± 0.5^†	1.9 ± 1.5	0.7 ± 0.1^†	1.1 ± 0.5
^99mTc-B2702p20	0.6 ± 0.2	1.4 ± 0.4	1.2 ± 0.3	6.1 ± 1.1	1.0 ± 0.4	11.1 ± 2.0	0.2 ± 0.1	0.2 ± 0.1	2.2 ± 0.6^†	0.5 ± 0.2	0.9 ± 0.1^†	1.2 ± 0.8

Data are mean ± SE %ID/g. *P < 0.05 vs. right carotid. ^†P < 0.05 vs. ^99mTc-B2702p.