TABLE 1

Overview of Rate Constants of 1TCM and 2TCM for ¹⁸F-JNJ-42259152 and Different Brain Regions

Model	Putamen	Caudate nucleus	Ventral striatum	Substantia nigra	Thalamus	Frontal cortex	Cerebellum	Global
1TCM
K₁	0.038 ± 0.006	0.031 ± 0.006	0.027 ± 0.006	0.016 ± 0.003	0.021 ± 0.005	0.017 ± 0.004	0.031 ± 0.007	0.026 ± 0.009
k₂	0.027 ± 0.004	0.037 ± 0.005	0.045 ± 0.006	0.044 ± 0.008	0.075 ± 0.015	0.073 ± 0.013	0.117 ± 0.032	0.060 ± 0.032
2TCM
K₁	0.044 ± 0.006	0.033 ± 0.007	0.030 ± 0.007	0.022 ± 0.004	0.028 ± 0.005	0.022 ± 0.004	0.038 ± 0.009	0.031 ± 0.010
k₂	0.050 ± 0.017	0.046 ± 0.011	0.063 ± 0.015	0.094 ± 0.015	0.136 ± 0.010	0.131 ± 0.011	0.182 ± 0.038	0.100 ± 0.051
k₃	0.035 ± 0.047	0.005 ± 0.006	0.010 ± 0.009	0.026 ± 0.012	0.012 ± 0.004	0.010 ± 0.004	0.008 ± 0.004	0.015 ± 0.021
k₄	0.044 ± 0.028	0.029 ± 0.043	0.028 ± 0.023	0.035 ± 0.012	0.019 ± 0.007	0.015 ± 0.007	0.014 ± 0.007	0.026 ± 0.024

Data are mean ± SD.