TABLE 1

Characteristics of Study Cohort at Baseline (n = 80)

CharacteristicTotal or median ± IQR
Age (y)60.9 ± 15.9
Sex
 Male58 (73%)
 Female22 (27%)
Baseline tumor marker level
 Carcinoembryonic antigen (ng/mL)129.0 ± 526.0
 Cancer antigen 19-9 (U/mL)85.6 ± 359.0
Hepatic tumor burden > 25%23 (29%)
Extrahepatic metastasis29 (36%)
Location of extrahepatic metastasis
 Lymph node12 (15%)
 Lung12 (15%)
 Other3 (4%)
 Multiple2 (3%)
Radioactivity delivered (GBq)1.8 ± 0.5
Time between initial diagnosis and radioembolization (wk)118 ± 87
Pretreatment
 Surgery
  Hemihepatectomy8 (10%)
  Partial liver resection19 (24%)
 Chemotherapies
  FOLFOX59 (74%)
  FOLFIRI67 (84%)
  Anti-VEGF/EGFR mAb65 (81%)
  Other31 (39%)
  Local therapy18 (23%)
Baseline PET parameters (mean of 3 lesions)
 Metabolic volume (cm3)24.4 ± 47.8
 Total lesion glycolysis (g)186.9 ± 484.3
 SUVpeak (g/cm3)9.8 ± 4.7
 SUVmax (g/cm3)11.5 ± 6.3
  • IQR = interquartile range; FOLFOX = folinic acid, fluorouracil, and oxaliplatin; FOLFIRI = folinic acid, fluorouracil, and irinotecan; VEGF = vascular endothelial growth factor; EGFR = epidermal growth factor receptor; mAb = monoclonal antibody.