Molecular Determinants and nAChR Subtype Binding Affinity of 2-FA and AZAN (17)
| Ki (nM) | |||||||||
| Radioligand | MW (Da) | logD7.4* | α4β2 | α2β2 | α2β4 | α3β2 | α3β4 | α4β4 | α6β2 |
| 2-18F-FA | 182 | −1.4 | 1.33 | 1.44 | 181 | 3.02 | 3680 | 188 | — |
| 18F-AZAN | 283 | 1.0 | 0.26 | 0.26 | 7.8 | 4 | 310 | 6.2 | 0.95 |
MW = molecular weight.
↵* Experimental lipophilicity, octanol/aqueous buffer, pH 7.4.