TABLE 1

Demographics, Overview of Modalities, and Results

Mouse strain	Sex	Age (mo)	Weight (g)	Drop-out due to death at or after PET scan (n)	PET scan successful (n)	Hemispheres (n)		PET		β-Amyloid plaque load (%)	Autoradiography cortex-to-cerebellum ratio
Mouse strain	Sex	Age (mo)	Weight (g)	Drop-out due to death at or after PET scan (n)	PET scan successful (n)	Histochemistry	Autoradiography	SUVR	BP_ND	β-Amyloid plaque load (%)	Autoradiography cortex-to-cerebellum ratio
APP-Swe	M	10	28.5 ± 3.9	3	5			0.95 ± 0.02	−0.05 ± 0.02
		13	28.9 ± 3.9		2	2	2	0.94 ± 0.03	−0.04 ± 0.03	0.35 ± 0.41	1.03 ± 0.04
C57BL/6 (WT)	M	10	35.0 ± 1.9	1	5			0.96 ± 0.02	−0.03 ± 0.02
		13	42.5 ± 4.2^*		2			0.97 ± 0.02	−0.03 ± 0.02
APP-Swe	F	13	26.7 ± 2.4		10			0.97 ± 0.03	−0.03 ± 0.04
		16	26.7 ± 1.8	3	8			1.04 ± 0.07^†	0.04 ± 0.07^*
		20	27.6 ± 2.3	2	5	8	2	1.13 ± 0.11^‡	0.10 ± 0.11^†	4.06 ± 2.78	1.51 ± 0.18
C57BL/6 (WT)	F	13	25.4 ± 1.6	2	8			0.97 ± 0.02	−0.03 ± 0.02
		16	25.5 ± 0.9		8			0.97 ± 0.02	−0.03 ± 0.03
		20	26.4 ± 2.5		6	2	2	0.98 ± 0.01	−0.02 ± 0.02	0	0.98 ± 0.02

↵* P < 0.05, 2-sample t test.
↵† P < 0.01, 2-sample t test.
↵‡ P < 0.001, 2-sample t test.
Pilot (male mice; 10–13 mo) and main study (female mice; 13–20 mo): heterozygous APP-Swe mice and age- and sex-matched C57BL/6 (control group) mice were used. Data are mean ± SD.