Plasma Pharmacokinetic Parameters After Intravenous Administration of BAY 86-7548
| Total radioactivity | Unchanged tracer | |||||||
| Parameter | Cmax (%ID/mL) | tmax* (min) | AUC(0-tlast) (%ID*min/mL) | Cmax (pmol/L) | tmax* (min) | AUC(0-tlast) (pmol*h/L) | CL† (L/h) | t1/2† (min) |
| Arithmetic mean | 0.0106 | 10.6 | 0.0116 | 438 | 10.6 | 157 | 55.5 | 81.0 |
| Arithmetic SD | 0.00766 | 1.88 | 0.00174 | 380 | 1.88 | 46.6 | 12.8 | 21.5 |
| Coefficient of variation (%) | 72.6 | 11.0 | 15.0 | 86.8 | 11.0 | 29.7 | 23.1 | 26.5 |
↵* Median, minimum, and maximum are listed instead of arithmetic mean, SD, and coefficient of variation.
↵† Values have to be regarded as estimates, because sampling time was not sufficient to describe terminal elimination phase adequately.
Injected dose of BAY 86-7548 was 140 MBq (total mass ≤ 28 µg) and number of experiments 5.
Cmax = maximum concentration; %ID = percentage injected dose; tmax = time of maximum; AUC = area under curve; CL = total clearance; t1/2 = plasma half-life