TABLE 2

Comparison of ¹⁸F-AZD4694 and ¹¹C-PiB SUVRs and Effect Sizes (d) in HCs and AD Subjects

	¹⁸F-AZD4694			¹¹C-PiB
Region	HC	AD	d ¹⁸F-AZD4694	HC	AD	d ¹¹C-PiB
Dorsolateral prefrontal	1.21 ± 0.22	2.28 ± 0.50^*	2.8	1.24 ± 0.25	2.41 ± 0.73^†	2.2
Ventrolateral prefrontal	1.29 ± 0.26	2.57 ± 0.58^*	2.8	1.31 ± 0.29	2.62 ± 0.67^*	2.6
Orbitofrontal	1.31 ± 0.27	2.48 ± 0.52^*	2.8	1.32 ± 0.30	2.32 ± 0.39^‡^*	2.9
Gyrus rectus	1.34 ± 0.27	2.58 ± 0.55^*	2.9	1.35 ± 0.28	2.47 ± 0.43^‡	3.1
Anterior cingulate	1.21 ± 0.26	2.39 ± 0.59^*	2.6	1.23 ± 0.31	2.42 ± 0.55^*	2.6
Precuneus and posterior cingulate	1.28 ± 0.32	2.76 ± 0.43^‡	4.0	1.31 ± 0.36	2.81 ± 0.46^‡	3.6
Parietal	1.21 ± 0.29	2.27 ± 0.46^‡	2.8	1.26 ± 0.32	2.38 ± 0.58^*	2.4
Lateral occipital	1.38 ± 0.18	1.97 ± 0.42^†	1.9	1.42 ± 0.22	2.06 ± 0.48^†	1.7
Lateral temporal	1.31 ± 0.21	2.53 ± 0.49^‡	3.2	1.35 ± 0.22	2.54 ± 0.51^*	3.0
Mesial temporal	1.32 ± 0.14	1.72 ± 0.23^*	2.1	1.28 ± 0.14	1.70 ± 0.34^†	1.6
Caudate nuclei	1.42 ± 0.22	2.62 ± 0.34^‡	4.2	1.39 ± 0.26	2.46 ± 0.30^‡	3.8
Putamen	1.36 ± 0.17	2.18 ± 0.22^‡	4.2	1.36 ± 0.20	2.14 ± 0.23^‡	3.7
Thalamus	1.36 ± 0.17	1.75 ± 0.18^*	2.3	1.28 ± 0.20	1.74 ± 0.22^*	2.2
Pons	2.13 ± 0.16	2.31 ± 0.59	0.4	2.22 ± 0.22	2.35 ± 0.59	0.3
White matter	1.83 ± 0.21	2.08 ± 0.37	0.8	1.83 ± 0.21	2.13 ± 0.53	0.8
Neocortex^†	1.28 ± 0.25	2.41 ± 0.50^‡	2.9	1.30 ± 0.28	2.44 ± 0.55^*	2.6