TABLE 5

Results of Interregional Correlation Analysis of ROI Compensation in LE and HE Prodromal AD Patients

				Peak level
	Cluster level				Talairach coordinates
Analysis	Cluster extent	Corrected P	Cortical region	Maximum z score	x	y	z	Cortical region	BA
LE	1,286	0.026	R frontal	4.31	22	28	−18	Middle frontal gyrus	11
			R frontal	4.23	30	30	−15	Inferior frontal gyrus	47
			R frontal	4.12	18	17	−11	Subcallosal gyrus	47
			R frontal	4.1	52	28	6	Inferior frontal gyrus	45
			R frontal	3.97	42	49	16	Middle frontal gyrus	46
			R frontal	3.95	48	29	−2	Inferior frontal gyrus	45
			R frontal	3.9	46	41	4	Inferior frontal gyrus	46
			R frontal	3.87	38	31	−12	Inferior frontal gyrus	47
			R limbic	3.81	8	34	−12	Anterior cingulate	32
HE	11,303	0.0001	L frontal	17.2	−50	3	13	Precentral gyrus	44
			L occipital	16	−16	−68	2	Lingual gyrus	18
			R frontal	15.9	30	−13	47	Middle frontal gyrus	6
			R frontal	15.6	36	−8	37	Precentral gyrus	6
			R frontal	14.3	22	16	49	Superior frontal gyrus	8
			L limbic	8.84	−18	−47	−4	Parahippocampal gyrus	19
			L temporal	8.22	−40	8	−31	Superior temporal gyrus	38
			L temporal	5.61	−61	−37	−8	Middle temporal gyrus	21
			L temporal	5.39	−63	−24	−21	Inferior temporal gyrus	20
			L parietal	5.12	−20	−46	52	Precuneus	7
			L parietal	4.96	−18	−47	36	Precuneus	31
			R temporal	4.90	55	−21	−23	Fusiform gyrus	20
			R temporal	4.80	59	−11	−18	Inferior temporal gyrus	21
			R frontal	4.78	10	54	21	Superior frontal gyrus	9
			R frontal	4.4	22	33	37	Middle frontal gyrus	8
			L sublobar	3.96	−30	10	−2	Claustrum
			R temporal	3.78	48	17	−13	Superior temporal gyrus	38
	2,000	0.003	L cerebellum	14.6	−36	−54	−36	Cerebellar tonsil

P values of <0.001 (uncorrected at voxel level) and <0.05 (FDR-corrected for multiple comparisons at cluster level) were accepted as statistically significant. In cluster level section, reported for each statistically significant cluster are number of voxels, corrected P value, and cortical region where cluster was found. In peak level section, reported for each significant cluster are z score, peak coordinates, corresponding cortical region, and BA.