Biodistribution of 177Lu-ABY-027 (Injected Dose, 10 μg) in BALB/C nu/nu Mice Bearing HER2-Expressing SKOV-3 Xenografts
| Concentration of radioactivity (%ID/g) | ||||||
| Organ | 4 h | 1 d | 2 d | 3 d | 7 d | 14 d |
| Tumor | 1.1 ± 0.5 | 8 ± 1 | 17 ± 7 | 15 ± 3 | 7 ± 2 | 1.3 ± 0.2 |
| Blood | 5 ± 1 | 8 ± 2 | 5.3 ± 0.4 | 3.4 ± 0.4 | 0.39 ± 0.05 | 0.020 ± 0.003 |
| Heart | 1.3 ± 0.3 | 2.7 ± 0.5 | 2.4 ± 0.3 | 1.9 ± 0.2 | 0.7 ± 0.2 | 0.21 ± 0.04 |
| Lung | 2.1 ± 0.4 | 4.1 ± 0.7 | 3.5 ± 0.5 | 2.4 ± 0.2 | 0.6 ± 0.1 | 0.13 ± 0.03 |
| Liver | 1.0 ± 0.2 | 2.8 ± 0.8 | 3.0 ± 0.7 | 2.5 ± 0.3 | 1.2 ± 0.2 | 0.52 ± 0.03 |
| Spleen | 0.6 ± 0.1 | 2.3 ± 0.5 | 2.9 ± 0.5 | 2.5 ± 0.6 | 1.9 ± 0.6 | 1.0 ± 0.6 |
| Pancreas | 0.45 ± 0.06 | 1.3 ± 0.2 | 1.0 ± 0.2 | 0.8 ± 0.2 | 0.27 ± 0.05 | 0.10 ± 0.03 |
| Stomach | 0.41 ± 0.05 | 1.5 ± 0.2 | 1.5 ± 0.6 | 0.9 ± 0.1 | 0.25 ± 0.04 | 0.08 ± 0.01 |
| Kidney | 2.6 ± 0.4 | 4.3 ± 0.8 | 3.9 ± 0.6 | 2.98 ± 0.09 | 1.3 ± 0.2 | 0.39 ± 0.06 |
| Muscle | 1.4 ± 0.4 | 1.3 ± 0.2 | 1.4 ± 0.4 | 0.9 ± 0.2 | 0.36 ± 0.08 | 0.09 ± 0.03 |
| Bone | 0.7 ± 0.2 | 1.3 ± 0.2 | 1.2 ± 0.4 | 1.1 ± 0.2 | 0.5 ± 0.3 | 0.5 ± 0.2 |
| Intestines* | 0.9 ± 0.3 | 1.9 ± 0.5 | 3 ± 2 | 1.3 ± 0.4 | 0.40 ± 0.07 | 0.10 ± 0.02 |
| Carcass* | 58 ± 15 | 46 ± 2 | 39 ± 2 | 32 ± 2 | 12 ± 1 | 6.1 ± 0.4 |
↵* Data for intestines with content and carcass are presented as %ID per whole sample.
Data are presented as average of %ID/g ± SD, n = 4.