TABLE 1

Biodistribution of Radioiodinated rECP in Mice With or Without Heparinase III Treatment

TissueWithout heparinase III (%ID/g)With heparinase III (%ID/g)P (t test)
Blood1.35 ± 0.231.85 ± 0.330.011
Muscle1.64 ± 0.131.24 ± 0.05<0.001
Bone0.63 ± 0.050.74 ± 0.04<0.001
Brain0.22 ± 0.040.21 ± 0.05>0.050
Lung2.98 ± 0.241.26 ± 0.65<0.001
Heart2.51 ± 0.321.31 ± 0.24<0.001
Liver3.54 ± 0.631.86 ± 0.42<0.001
Stomach45.53 ± 2.1434.32 ± 5.12<0.001
Pancreas4.32 ± 0.522.14 ± 0.12<0.001
Spleen8.12 ± 0.432.55 ± 0.33<0.001
Small intestine7.16 ± 0.354.53 ± 0.72<0.001
Kidney23.54 ± 3.3215.54 ± 1.41<0.001
Thyroid15.32 ± 2.1310.53 ± 3.230.016

  • Data represent mean ± SD of values obtained from 6 mice.