TABLE 2

Results of Localization Studies, Operative and Histologic Findings, and Biochemical Cure in Patients Undergoing Reoperation

Patient no.	¹²³I/^99mTc-sestamibi	SPECT/CT	¹¹C-methionine PET/CT	SVS	Operative finding	Histology	Biochemical cure
1	Right lower quadrant	Negative	Right lower quadrant	Right upper and lower quadrant	Right lower parathyroid	Adenoma	Yes
2	Right upper quadrant	Right upper quadrant	Right thyroid	Middle	Right thyroid lobe removed, adenoma (in the middle)	Adenoma	Yes
3	Negative	Negative	Negative	Right lower quadrant	None	—	No
4	Right lower quadrant	Right lower quadrant	Right lower quadrant	Right lower quadrant	Right upper parathyroid, aberrantly low location	Hyperplasia	Yes
5	Negative	Negative	Right upper quadrant	Negative	Right upper parathyroid	Atypical adenoma	Yes
6	Right lower quadrant	Negative	Right lower quadrant	Right upper quadrant	Right thyroid lobe removed, intrathyroidal parathyroid	Adenoma	Yes
7	Left lower quadrant	Negative	LEFT lower quadrant	Left lower quadrant	Left lower parathyroid	Adenoma	Yes
8	Negative	Negative	Right lower quadrant	Left lower quadrant	Right lower quadrant	Thyroid tissue	No^*
9	Right and left lower quadrant	Left lower quadrant	Left lower quadrant	Right lower quadrant	Right and left upper parathyroids	Hyperplasia; 2 glands	Yes
10	Mediastinum	Negative	Mediastinum	Left lower quadrant	Mediastinal parathyroid	Hyperplasia	Yes
11	Left lower quadrant	Negative	Left lower quadrant	Right and left upper quadrant	Left lower parathyroid, in the carotid sheath	Adenoma	Yes
12	Right lower quadrant	Right lower quadrant	Right lower quadrant	Right upper quadrant	Right lower parathyroid	Adenoma	Yes
13	Negative	Negative	Right upper quadrant	Right lower quadrant	Right upper parathyroid	Hyperplasia	Yes^†
14	Negative	Negative	Negative	Right lower quadrant	Left lower parathyroid	Adenoma	Yes
15	Negative	Negative	Negative	Left lower quadrant	Nodule from right thyroid lobe	Thyroid tissue	No^*
16	Right lower quadrant	Not available	Right lower quadrant	Left lower quadrant	Right lower parathyroid	Adenoma	Yes
17	Negative	Not available	Mediastinum	Mediastinum	Mediastinal parathyroid	Adenoma	Yes
18	Left lower quadrant	Negative	Negative	Left upper quadrant and mediastinum	Both left parathyroids	Hyperplasia; 2 glands	Yes
19	Negative	Negative	Right lower quadrant	Not available	Nodules from right lower quadrant	Unclear	Yes^‡
20	Right lower quadrant	Negative	Right lower quadrant	Not available	Right lower parathyroid	Hyperplasia	Yes
21	Right lower quadrant	Right lower quadrant	Right lower quadrant	Not available	Right upper parathyroid, aberrantly low location	Hyperplasia	Yes

↵* Both sides of neck were explored for these patients.
↵† This patient had normal serum Ca-ion (1.24 mmol/L; reference, 1.16–1.30 mmol/L) on first postoperative day but not 50% decrease in her PTH concentration (preoperative PTH, 101 ng/L; and postoperative, 81 ng/L; reference, 8–73 ng/L). She was considered cured because histology confirmed hyperplasia and she no longer fulfills criteria for reoperation.
↵‡ This patient was cured after operation as evidenced by normal biochemical findings on first postoperative day (serum Ca-ion, 1.19 mmol/L; reference, 1.16–1.30 mmol/L; and PTH, 11 ng/L, compared with 85 ng/L preoperatively; reference, 8–73 ng/L), although histology did not demonstrate parathyroid tissue.