Influence of Injected 2Rs15d Nanobody Mass on Biodistribution of 68Ga-NOTA-2Rs15d at 1 Hour After Injection
| Injected 2Rs15d mass | |||
| Tissue/organ | 0.1 μg | 1 μg | 10 μg |
| Blood | 1.07 ± 0.24 | 0.72 ± 0.18 | 0.50 ± 0.17 |
| Heart | 0.53 ± 0.22 | 0.27 ± 0.05 | 0.17 ± 0.02 |
| Lungs | 8.29 ± 4.89 | 1.00 ± 0.59 | 0.53 ± 0.13 |
| Liver | 7.43 ± 1.89 | 3.03 ± 1.00 | 2.90 ± 0.26 |
| Spleen | 2.65 ± 0.89 | 0.99 ± 0.36 | 0.71 ± 0.19 |
| Kidney | 29.00 ± 3.22 | 42.90 ± 8.57 | 38.07 ± 5.69 |
| Intestine | 0.38 ± 0.12 | 0.37 ± 0.20 | 0.21 ± 0.08 |
| Tumor | 2.49 ± 0.68 | 3.45 ± 1.29 | 4.23 ± 0.99 |
| Muscle | 0.26 ± 0.08 | 0.24 ± 0.11 | 0.17 ± 0.15 |
| Tumor-to-muscle | 11.09 ± 6.22 | 15.38 ± 4.82 | 34.39 ± 15.69 |
| Tumor-to-blood | 2.33 ± 0.90 | 4.92 ± 1.62 | 8.86 ± 2.61 |
Data are expressed as mean %IA/g ± SD (n = 6).