TABLE 2
Comparison of β-Amyloid Binding and Blood Flow Parameters Between β-Amyloid–Positive AD (n = 8) and –Negative HC (n = 9) Groups
| Mean values of 4 cortical regions* | ||||
| Parameter | AD | HC | Cohen d | P |
| 2TCM | ||||
 (mL⋅cm−3⋅min−1) | 0.195 ± 0.019 | 0.246 ± 0.037 | NA | 0.003 |
 (mL⋅cm−3) | 10.62 ± 2.57 | 6.84 ± 1.07 | NA | 0.001 |
 (mL⋅cm−3⋅min−1) | 0.252 ± 0.018 | 0.281 ± 0.070 | NA | 0.28 |
 (mL⋅cm−3) | 6.05 ± 1.24 | 5.45 ± 1.13 | NA | 0.32 |
 (mL⋅cm−3) | 4.57 ± 1.44 | 1.38 ± 0.47 | 3.25 | <0.0001 |
| DVR (2TCM) | 1.75 ± 0.13 | 1.27 ± 0.11 | 4.22 | <0.0001 |
| Reference tissue models | ||||
| DVR (MRTM) | 1.54 ± 0.067 | 1.18 ± 0.11 | 4.03 | <0.0001 |
| SUVR | 1.79 ± 0.14 | 1.30 ± 0.12 | 4.03 | <0.0001 |
↵* Frontal, lateral temporal, parietal, and posterior cingulate cortices.
NA = not applicable.
Data are expressed as mean ± SD. Effect size in group comparison was determined by Cohen d, and P values were calculated by Student t test (2-tailed, unpaired).