P | ||||
Parameter | Best group by cutoff level | 3-y LRC | 3-y DFS | 3-y OS |
All patients | ||||
SUVmax(9) 1 | SUVmax(9) ≥ 6.1* | 0.17 | 0.12 | 0.52 |
GTVCT 1 | GTVCT < 6.5 cm3 | 100 (80–100) vs. 76 (60–92): 0.044† | 0.27 | 0.13 |
GTVVIS 1 | GTVVIS < 6.5 cm3 | 100 (75–100) vs. 79 (65–93): 0.092 | 0.20 | 0.26 |
Δ SUVmax(9) 1–2 | Decrease ≥ 45%‡ | 92 (80–100) vs. 72 (51–93): 0.066 | 88 (75–100) vs. 63 (41–85): 0.035† | 0.23 |
Δ GTVVIS 1–2 | Decrease ≥ 41%* | 0.21 | 91 (80–100) vs. 65 (46–84): 0.037† | 0.86 |
Δ GTVVIS 1–3 | Decrease ≥ 78%* | 100 (78–100) vs. 68 (41–94): 0.021† | 100 (78–100) vs. 56 (30–83): 0.005† | 80 (54–100) vs. 48 (6–89): 0.084 |
Radiotherapy | ||||
SUVmax(9) 1 | SUVmax(9) < 6.6‡ | 95 (85–100) vs. 70 (41–99): 0.075 | 90 (77–100) vs. 59 (31–87): 0.044† | 0.59 |
GTVCT 1 | GTVCT < 6.5 cm3 | 100 (79–100) vs. 73 (50–96): 0.048† | 0.26 | 0.25 |
GTVVIS 1 | GTVVIS < 6.5 cm3 | 0.11 | 0.20 | 0.44 |
Δ SUVmax(9) 1–2 | Decrease ≥ 45% | 0.48 | 0.20 | 0.65 |
Δ GTVVIS 1–2 | Decrease ≥ 47%* | 0.95 | 0.20 | 0.27 |
Δ GTVVIS 1–3 | Decrease > 77%* | 100 (72–100) vs. 66 (34–98): 0.05 | 100 (72–100) vs. 53 (23–83): 0.013† | 0.12 |
Chemoradiotherapy | ||||
SUVmax(9) 1 | SUVmax(9) ≥ 6.6* | 100 (63–100) vs. 57 (20–94): 0.044† | 100 (63–100) vs. 57 (20–94): 0.044† | 100 (63–100) vs. 57 (8–100): 0.080 |
GTVCT 1 | GTVCT < 6.5 cm3 | 0.63 | 0.63 | 0.66 |
GTVVIS 1 | GTVVIS < 6.5 cm3 | 0.63 | 0.63 | 0.66 |
Δ SUVmax(9) 1–2 | Decrease ≥ 45% | 100 (54–100) vs. 57 (20–94): 0.081 | 100 (54–100) vs. 57 (20–94): 0.081 | 100 (54–100) vs. 57 (8–100): 0.10 |
Δ GTVVIS 1–2 | Decrease ≥ 31%* | 100 (59–100) vs. 50 (10–90): 0.039† | 100 (59–100) vs. 50 (10–90): 0.039† | 100 (59–100) vs. 56 (7–100): 0.079 |
Δ GTVVIS 1–3 | Not tested§ | Not tested§ | Not tested§ | Not tested§ |
↵* Dichotomization by median value.
↵† P < 0.05.
↵‡ Dichotomization value found through receiver-operating-characteristic analysis.
↵§ Too few subjects for testing (n = 7).
GTVCT = visually delineated gross tumor volume on CT; Δ = difference between baseline scans (1) and subsequent scans (2 or 3).
Numbers after PET/CT parameters refer to first, second, or third scan. For survival data with P ≤ 0.1, 3-y survival data per group are given (%), with 95% CI in parentheses; for survival differences with P > 0.1, only P value is given.