TABLE 2

Outcome as Function of (Changes in) PET/CT Parameters

P
ParameterBest group by cutoff level3-y LRC3-y DFS3-y OS
All patients
 SUVmax(9) 1SUVmax(9) ≥ 6.1*0.170.120.52
 GTVCT 1GTVCT < 6.5 cm3100 (80–100) vs. 76 (60–92): 0.0440.270.13
 GTVVIS 1GTVVIS < 6.5 cm3100 (75–100) vs. 79 (65–93): 0.0920.200.26
 Δ SUVmax(9) 1–2Decrease ≥ 45%92 (80–100) vs. 72 (51–93): 0.06688 (75–100) vs. 63 (41–85): 0.0350.23
 Δ GTVVIS 1–2Decrease ≥ 41%*0.2191 (80–100) vs. 65 (46–84): 0.0370.86
 Δ GTVVIS 1–3Decrease ≥ 78%*100 (78–100) vs. 68 (41–94): 0.021100 (78–100) vs. 56 (30–83): 0.00580 (54–100) vs. 48 (6–89): 0.084
Radiotherapy
 SUVmax(9) 1SUVmax(9) < 6.695 (85–100) vs. 70 (41–99): 0.07590 (77–100) vs. 59 (31–87): 0.0440.59
 GTVCT 1GTVCT < 6.5 cm3100 (79–100) vs. 73 (50–96): 0.0480.260.25
 GTVVIS 1GTVVIS < 6.5 cm30.110.200.44
 Δ SUVmax(9) 1–2Decrease ≥ 45%0.480.200.65
 Δ GTVVIS 1–2Decrease ≥ 47%*0.950.200.27
 Δ GTVVIS 1–3Decrease > 77%*100 (72–100) vs. 66 (34–98): 0.05100 (72–100) vs. 53 (23–83): 0.0130.12
Chemoradiotherapy
 SUVmax(9) 1SUVmax(9) ≥ 6.6*100 (63–100) vs. 57 (20–94): 0.044100 (63–100) vs. 57 (20–94): 0.044100 (63–100) vs. 57 (8–100): 0.080
 GTVCT 1GTVCT < 6.5 cm30.630.630.66
 GTVVIS 1GTVVIS < 6.5 cm30.630.630.66
 Δ SUVmax(9) 1–2Decrease ≥ 45%100 (54–100) vs. 57 (20–94): 0.081100 (54–100) vs. 57 (20–94): 0.081100 (54–100) vs. 57 (8–100): 0.10
 Δ GTVVIS 1–2Decrease ≥ 31%*100 (59–100) vs. 50 (10–90): 0.039100 (59–100) vs. 50 (10–90): 0.039100 (59–100) vs. 56 (7–100): 0.079
 Δ GTVVIS 1–3Not tested§Not tested§Not tested§Not tested§
  • * Dichotomization by median value.

  • P < 0.05.

  • Dichotomization value found through receiver-operating-characteristic analysis.

  • § Too few subjects for testing (n = 7).

  • GTVCT = visually delineated gross tumor volume on CT; Δ = difference between baseline scans (1) and subsequent scans (2 or 3).

  • Numbers after PET/CT parameters refer to first, second, or third scan. For survival data with P ≤ 0.1, 3-y survival data per group are given (%), with 95% CI in parentheses; for survival differences with P > 0.1, only P value is given.