TABLE 1

Patient Characteristics

CharacteristicNumber of patients
American Joint Committee on Cancer clinical stage*
 IIA11 (21.5%)
 IIB13 (25.5%)
 IIIA12 (23.5%)
 IIIB14 (27.5%)
 IIIC1 (2%)
Tumor type
 Invasive ductal, no special type45 (88%)
 Metaplastic3 (6%)
 Lobular3 (6%)
Grade
 14 (8%)
 228 (55%)
 317 (33%)
 Unknown2 (4%)
ER status
 Positive30 (59%)
 Negative21 (41%)
HER2 status
 Positive12 (23.5%)
 Negative39 (76.5%)
Triple-negative status
 Triple-negative13 (25.5%)
 Not triple-negative38 (74.5%)
Surgery
 Breast-conserving surgery25 (49%)
 Mastectomy26 (51%)
Pathologic response
 Responders27 (53%)
 Nonresponders24 (47%)
  • * Version 7 (16) according to clinical examination and conventional imaging findings.

  • Tumors were considered positive for ER (estrogen receptor) if >10% of cells showed staining by immunohistochemistry.

  • Tumors were considered to be positive for HER2 if >30% of invasive tumor cells showed definite membrane staining resulting in so-called fishnet appearance.