TABLE 3

¹¹C-Verapamil Radioactivity K₁, Q, and ER Estimates Grouped by CsA Blood Concentration

		Before CsA			During CsA			% change due to CsA
CsA (μM)	No. of animals	K₁	Q	ER	K₁	Q	ER	K₁	Q	ER
Maternal brain
4.7 ± 1.4 (range, 2.9–6.2)	4	0.35 ± 0.19	0.74 ± 0.14	0.49 ± 0.24	0.64 ± 0.18	0.83 ± 0.21	0.84 ± 0.40	120 ± 110	12 ± 8	99 ± 98
14.3 ± 6.4 (range, 7.8–21.0)	6	0.20 ± 0.07	0.92 ± 0.30	0.23 ± 0.05	0.87 ± 0.20	0.90 ± 0.24	1.0 ± 0.19	372 ± 193	0 ± 20	361 ± 123
Fetal liver
4.7 ± 1.4 (range, 2.9–6.2)	4	0.17 ± 0.09	0.67 ± 0.22	0.28 ± 0.19	0.36 ± 0.18	0.72 ± 0.25	0.55 ± 0.33	115 ± 28	9 ± 17	102 ± 54
14.3 ± 6.4 (range, 7.8–21.0)	4	0.15 ± 0.03	0.84 ± 0.20	0.20 ± 0.10	0.43 ± 0.17	0.68 ± 0.21	0.68 ± 0.36	174 ± 75	−18 ± 22	238 ± 61

Data are given as mean ± SD. K₁ and Q are in units of mL⋅min⁻¹⋅g⁻¹.