Limitations and Issues Identified in this Trial, as Well as Potential Solutions to Investigate Them
| Issue | Potential solution |
| Ratio of 18F− and 18F-FDG dosages | Conduct dose modeling or phantom studies to determine optimal ratio of 18F− to 18F-FDG for combined scan |
| Sensitivity and specificity of 18F−/18F-FDG PET/CT | Conduct prospective trials with pathology or follow-up evaluation of detected lesions |
| Quantitation of radiotracer uptake | Conduct experiments to determine influence of 18F− uptake on 18F-FDG maximum standardized uptake value and vice versa |
| Interpretation of follow-up studies | Conduct prospective studies to evaluate feasibility or usefulness of 18F−/18F-FDG PET/CT in posttherapy setting |
| 18F− nonspecific uptake | Analyze CT data to increase specificity |