TABLE 1

Pharmacokinetic Parameters of ¹¹C-SC-62807 in Wild-Type and Bcrp^–/– Mice

Pharmacokinetic parameter	Wild-type mice	Bcrp^–/– mice	Ratio of Bcrp^–/– to wild-type
AUC_{blood,0–30 min} (% dose × min/mL)	42 ± 18	93 ± 19^*	2.2 ± 1.1
AUC_{liver,0–30 min} (% dose × min/mL)	369 ± 85	535 ± 76^†	1.5 ± 0.4
AUC_{kidney,0–30 min} (% dose × min/mL)	170 ± 36	1,119 ± 126^‡	6.6 ± 1.6
K_p,liver,AUC (mL/g of liver)	8.8 ± 3.0	5.6 ± 0.8	0.64 ± 0.24
K_p,kidney,AUC (mL/g of kidney)	4.0 ± 1.3	11.7 ± 2.3^*	2.9 ± 1.1
X_{bile,0–30 min} (% dose)	48 ± 3	13 ± 2^‡	0.28 ± 0.04
X_{urine,0–30 min} (% dose)	26 ± 5	3.0 ± 1.7^‡	0.11 ± 0.07
CL_{bile,blood,0–30 min} (mL/min/kg)	48 ± 19	5.1 ± 1.6^†	0.11 ± 0.05
CL_{renal,blood,0–30 min} (mL/min/kg)	25 ± 8	1.2 ± 0.7^*	0.046 ± 0.033
CL_{int,bile,liver} (mL/min/kg)	4.5 ± 0.8	1.2 ± 0.1^*	0.26 ± 0.05
CL_{int,urine,kidney} (mL/min/kg)	13 ± 2	0.12 ± 0.07^*	0.0088 ± 0.0051

↵* Unpaired t test, P < 0.01.
↵† Unpaired t test, P < 0.05.
↵‡ Unpaired t test, P < 0.001.
Each value represents mean ± SD (n = 3–4). Statistically significant difference was observed for several pharmacokinetic parameters in Bcrp^–/– mice, compared with wild-type.