Central Nervous System Binding Profile of FE-PEO
| Binding site | Ki (nM) | Binding site | Ki (nM) | Binding site | Ki (nM) | Binding site | Ki (nM) |
| 5-HT1A | >10,000 | α1A | >10,000 | D1 | >10,000 | KOR | 0.4 ± 0.02 |
| 5-HT1B | >10,000 | α1B | >10,000 | D2 | >10,000 | M1 | >10,000 |
| 5-HT1D | >10,000 | α1D | >1,0000 | D3 | >10,000 | M2 | >10,000 |
| 5-HT1E | >10,000 | α2B | >10,000 | D4 | >10,000 | M3 | >10,000 |
| 5-HT2A | >10,000 | α2C | >10,000 | D5 | >10,000 | M4 | 2,635 ± 420 |
| 5-HT2B | >10,000 | α2D | >10,000 | DAT | >10,000 | M5 | >10,000 |
| 5-HT2C | >10,000 | β1 | >10,000 | DOR | 1.6 ± 0.2 | MOR | 0.4 ± 0.03 |
| 5-HT3 | >10,000 | β2 | >10,000 | GABAA | >10,000 | NET | >10,000 |
| 5-HT5A | >10,000 | β3 | >10,000 | GABAB | >10,000 | SERT | >10,000 |
| 5-HT6 | >10,000 | BZP | 9,626 ± 2,385 | H1 | >10,000 | σ1 | 8,232 ± 1,439 |
| 5-HT7 | >10,000 | Ca2+ channel | >10,000 | H2 | 6,617 ± 1,000 | σ2 | 2,988 |
Ki determinations, receptor binding profiles, and agonist functional data were provided by National Institute of Mental Health Psychoactive Drug Screening Program, contract HHSN-271-2008-00025-C (NIMH PDSP). See home page of PDSP (http://pdsp.med.unc.edu) for documentation and experimental details. For mean Ki values < 10,000 nM, SEs are given in addition to mean values, with exception of σ2 (error not determined).