TABLE 1

VT Estimates for Selected ROIs Using 1TC Model for Baseline 11C-BU99008 Scans and Scans After Administration of BU224

VTCerebellumFrontal cortexHippocampusStriatumThalamus
Baseline (mL/cm3)*26.6 ± 4.129.3 ± 4.736.2 ± 7.943.6 ± 7.949.7 ± 11.0
After BU224 administration
 0.01 mg/kg†17.018.320.625.428.3
 5.00 mg/kg†8.18.810.510.610.9

  • ↵* Data are mean ± SD; n = 3.

  • ↵† n = 1.