Comparison of Parameters in Baseline (n = 10) Versus Propofol (n = 10) Scans
| Parameter | Baseline | Propofol | % change | P |
| Injected mass associated with radioactive dose (nmol/kg) | 0.092 ± 0.04 | 0.098 ± 0.03 | +6.5% | 0.35 |
| Radiochemical purity (%) | 97.6 ± 1.8 | 97.9 ± 0.7 | +0.3% | 0.33 |
| Plasma50% (min) | 9.66 ± 2.3 | 10.84 ± 2.7 | +12.2% | 0.09 |
| Tmax (min) | 1.36 ± 0.14 | 1.13 ± 0.12 | −16.9% | 0.00 |
| Parent plasma AUC0→120 | 4,803.2 ± 726.8 | 5,418.2 ± 637.2 | +12.8% | 0.02 |
% change = (propofol − baseline)/baseline; plasma50% (min) = time from peak to 50% decrease from peak of 11C-PBR28 concentration in arterial plasma; AUC0 → 120 = area under curve of 11C-PBR28 concentration in arterial plasma calculated from time 0 to 120 min.