TABLE 6

Effects of Variables on OS, PFS, and LPFS

	OS				PFS				LPFS
	Univariable		Multivariable		Univariable		Multivariable		Univariable		Multivariable
Characteristic	HR	P	HR	P	HR	P	HR	P	HR	P	Hazard ratio	P
Age^*	1.26 (0.86–1.83)	0.23	1.43 (0.95–2.17)	0.09	1.03 (0.74–1.44)	0.85			0.84 (0.50–1.39)	0.49
Male sex	1.13 (0.56–2.28)	0.73			1.29 (0.68–2.46)	0.44			0.94 (0.36–2.48)	0.90
Stage 1 or 2	1	0.42			1	0.81			1	0.64
Stage 3a	0.90 (0.32–2.56)				1.38 (0.51–3.72)				1.67 (0.36–7.70)
Stage 3b	1.47 (0.52–4.16)				1.28 (0.47–3.49)				1.06 (0.21–5.49)
Squamous cell carcinoma histology	1.04 (0.48–2.26)	0.91			0.86 (0.44–1.69)	0.67			0.57 (0.19–1.75)	0.33
SUVpeak^†	0.87 (0.63–1.18)	0.36			0.87 (0.65–1.16)	0.34			0.82 (0.54–1.24)	0.35
TLG^‡	0.93 (0.72–1.21)	0.59			0.82 (0.64–1.05)	0.11	1.06 (0.74–1.51)	0.76	0.73 (0.53–0.99)	0.04	0.91 (0.59–1.41)	0.68
High coarseness	3.48 (1.41–8.63)	0.007	4.86 (1.32–17.9)	0.02	3.18 (1.48–6.85)	0.003	2.41 (0.82–7.09)	0.11	6.69 (1.50–29.8)	0.01	5.56 (0.90–34.1)	0.06
High contrast	0.47 (0.20–1.10)	0.08	1.11 (0.41–2.99)	0.84	0.40 (0.19–0.85)	0.02	0.60 (0.24–1.48)	0.27	0.30 (0.09–1.07)	0.07	0.67 (0.16–1.48)	0.58
High busyness	0.51 (0.25–1.04)	0.06	1.12 (0.44–2.92)	0.80	0.46 (0.24–0.88)	0.02	0.97 (0.37–2.53)	0.95	0.36 (0.13–0.98)	0.05	1.18 (0.32–2.53)	0.80
High complexity	0.59 (0.28–1.25)	0.17	1.11 (0.43–2.87)	0.82	0.61 (0.32–1.18)	0.17	0.87 (0.40–1.92)	0.73	0.60 (0.22–1.62)	0.31

↵* Hazard ratios are reported for 10-unit increase in variable.
↵† Hazard ratios are reported for 5-unit increase in variable.
↵‡ Variable was analyzed on log scale.
Figures reported are hazard ratios and corresponding 95% CIs. For variables measured on continuous scale, hazard ratios are reported for 1-unit increase in that variable (unless otherwise indicated). Data in parentheses are 95% CIs.