TABLE 3

Set-up of α-Therapy Study Using 149Tb-cm09 and β-Therapy Study Using 161Tb-cm09 in KB Tumor–Bearing Nude Mice

Therapy studyMouse identificationTest agentInjection protocolAmount of radioactivity
α
 Control groupa1, a2, a3PBSDays 0 and 4
 Treated groupb1, b2, b3149Tb-cm09Days 0 and 41.1 and 1.3 MBq
β
 Control groupc1, c2, c3, c4, c5PBSDay 0
 Treated groupd1, d2, d3, d4, d5161Tb-cm09Day 011 MBq
  • *Irradiation of even highly enriched 152Gd targets would presumably result in only moderate yield and quality of 149Tb because of concomitant production of side products (150Tb, 151Tb) and 149mTb.